… use of IVIg, a comprehensive clinical guideline for the use of IVIg in … The pathogenic relevance
of FcRn in autoimmune bullous … The skin is usually affected in a UV-dependent fashion. …

… , and various skin blistering diseases severely impacts quality of … both FcRn and the family
of canonical FcγRs are central to IgG (… on how IVIg may modulate IgG-dependent autoimmune …

… In autoimmune bullous diseases, IVIGs can be used in an … explained by an exclusively
FcRn-dependent mechanism. Finally, it … The full text of this article hosted at iucr.org is unavailable …

… trials are completed, the information that IVIg preparations contain … of IgG derived from IVIg
administrations saturate the FcRn so … IVIg causes a dose-dependent downregulation on their …

… FcRn mAb which determined sustained dose-dependent … procedure applied to remove
total IgG from patient plasma using … Intravenous immunoglobulin (IVIG) treatment is utilized to …

… achieved complete remission on therapy within 2 months and … diminish blister formation in
a dose-dependent fashion.103, 105 … In the circulation, FcRn protects circulating IgG antibodies …

… blistering disease and is … of IVIG in IgG-mediated autoimmune diseases (Figure 1). These
proposed modes of action include saturation of the IgG protective neonatal FcR receptor (FcRn)…

… FcRn binds to the Fc portion of IgGs in a pH-dependent … state of knowledge of FcRn–IgG
immunobiology, with an … infectious diseases and cancer, and in the promotion of autoimmunity, …

… may be combined with intravenous immunoglobulin (IVIG) therapy. Clinically, IVIG administration
has been … Third line therapies are dependent on individual patient needs and include …

… Our current understanding of IVIg is dependent on the underlying disease process, and the
… FcRn appears to have an important role in autoimmune bullous disease as FcRn deficient …